MEDONEFARMA

MILRINONE

PRODUCT DESCRIPTION

Milrinone is a bipyridine derivative with positive inotropic and lusitropic effects that also results in peripheral vasodilation with minimal chronotropic effects over a therapeutic range of 100 to 300 ng/mL. As such, milrinone is used in decompensated congestive heart failure.

CHEMICAL NAME

2-Methyl-6-oxo-1,6-dihydro-3,4′-bipyridine-5-carbonitrile

Brand Names

Primacor, Corotrope

Category

Inotropic agent (cardiovascular)

DOSAGE FORM

Infusion solution, in D5W

  • 20mg/100mL
  • 40mg/200mL

Injectable solution

  • 1mg/mL

INDICATIONS

Milrinone increases the strength of your heart muscles and widens your blood vessels. It treats heart failure, which is a condition that prevents your heart from pumping very well.

NDC CODE

  • Milrinone Lactate Injection: 10 mL single dose vials in a box of 10, NDC 0143-9710-10
  • Milrinone Lactate Injection: 10 mL single dose vials in abox of 25, NDC 0143-9710-25
  • Milrinone Lactate Injection: 20 mL single dose vials in a box of 10, NDC 0143-9709-10
  • Milrinone Lactate Injection:50 mL single dose vial in a box of 1, NDC 0143-9708-01

STORAGE & SHELF LIFE

  • Shelf life: 3 years when unopened. The chemical and physical in-use stability has been demonstrated for 72 hours at room temperature (15-25°C) or at refrigerated condition (2-8°C).
  • Store between 20°C to 25°C (68°F to 77°F) [See USP Controlled Room Temperature]. Avoid freezing. Exposure of pharmaceutical products to heat should be minimized. Avoid excessive heat.

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